Programme
1st Day:
Thursday, 30th November 2017
08:00 - 08:45
Registration
08:45 - 09:00
Welcome
DI Dr. Michaela Fritz - Vice Dean Med University of Vienna
Prof. Dr. Ralph Schmid - Head Thoracic Surgery, Founder EACTS Regeneration Council
Prof. Dr. Michael Comer - Chairman PACT
DI Dr. Michaela Fritz - Vice Dean Med University of Vienna
Prof. Dr. Ralph Schmid - Head Thoracic Surgery, Founder EACTS Regeneration Council
Prof. Dr. Michael Comer - Chairman PACT
09:00 - 09:35
Chair: Keynote
Chair: Keynote
Infarct Healing as a Therapeutic Target
Ralph Schmid
Kai Christoph Wollert - Hannover Medical School, Germany
“Infarct Healing as a Therapeutic Target”
Ralph Schmid
Kai Christoph Wollert - Hannover Medical School, Germany
“Infarct Healing as a Therapeutic Target”
09:35 - 11:00
Chair:
Chair:
Secretome and Regeneration: New Kid on the Block
Jolanda Kluin, Erwin Tschachler
Massimiliano Gnecchi - University of Pavia, Italy
“Secretome and Regeneration: From Initial to Current Work”
Hendrik Jan Ankersmit - Medical University of Vienna, Austria
“Secretome-based Regeneration from Skin to Heart”
Michael Mildner - Medical University of Vienna, Austria
“Secretome and MOA“
Jolanda Kluin, Erwin Tschachler
Massimiliano Gnecchi - University of Pavia, Italy
“Secretome and Regeneration: From Initial to Current Work”
Hendrik Jan Ankersmit - Medical University of Vienna, Austria
“Secretome-based Regeneration from Skin to Heart”
Michael Mildner - Medical University of Vienna, Austria
“Secretome and MOA“
11:00 - 11:30
Coffee
11:30 - 13:00
Chairs:
Chairs:
ATMPs versus Biologicals
Monika Chabicovsky, Detlef Niese
Detlef Niese - Regulatory Affairs Consultant, Germany
“Bringing a Cellular Therapy to the Market: A Skin to Patient Story“ Tobias Ostler - Regenold, Germany
“Regulatory Affairs - from Science to Translation“
Monika Chabicovsky - MC Toxicology Consulting, Austria
“Safety Testing of Biologics and Advanced Therapies”
Michael Erb - Synlab, Germany
“Potency Assay Development of Drug Compounds in Regenerative Medicine”
Monika Chabicovsky, Detlef Niese
Detlef Niese - Regulatory Affairs Consultant, Germany
“Bringing a Cellular Therapy to the Market: A Skin to Patient Story“ Tobias Ostler - Regenold, Germany
“Regulatory Affairs - from Science to Translation“
Monika Chabicovsky - MC Toxicology Consulting, Austria
“Safety Testing of Biologics and Advanced Therapies”
Michael Erb - Synlab, Germany
“Potency Assay Development of Drug Compounds in Regenerative Medicine”
13:00 - 14:00
Lunch & Posters
14:00 - 15:20
Chairs:
Chairs:
Regulatory Affairs, GMP-Production and Clinical Trials
Ilona Reischl, Beatrix Reinprecht
Ilona Reischl - AGES, Vienna, Austria
“Regulatory Affairs – Update”
Anja Peterbauer-Scherb - Red Cross Upper Austria, Austria
“GMP Production: Regulatory Prerequisites”
Ulrich Jäger - Medical University of Vienna, Austria
“Delivering the Product to the Patient in a Clinical Trial Center“
Katharina Schallmoser - Paracelsus Medical University
Salzburg, Austria
“New Regulation for Ancilliary/Raw Materials for Cell Therapys“
Ilona Reischl, Beatrix Reinprecht
Ilona Reischl - AGES, Vienna, Austria
“Regulatory Affairs – Update”
Anja Peterbauer-Scherb - Red Cross Upper Austria, Austria
“GMP Production: Regulatory Prerequisites”
Ulrich Jäger - Medical University of Vienna, Austria
“Delivering the Product to the Patient in a Clinical Trial Center“
Katharina Schallmoser - Paracelsus Medical University
Salzburg, Austria
“New Regulation for Ancilliary/Raw Materials for Cell Therapys“
15:20 - 16:25
Chairs:
Chairs:
Adipose-derived Mesenchymal Stem Cells in
Ischemic Heart Diseases
Johann Wojta, Thomas Marti
Gemma Vilahur - Catalan Institute of
Cardiovascular Sciences, Spain
“Cell- or Paracrine- Mediated Reparative Effects in the
Infarct Heart”
Young Investigator Nominee: Ines Goncalves - Medical University of Vienna, Austria
“Differences in Stem Cell Processing Lead to Distinct Secretomes Secretion - Implications for Differential Results of Previous Clinical Trials of Stem Cell Therapy for Myocardial Infarction”
Young Investigator Nominee: Tanja Wagner - Medical University of Vienna, Austria
“Extracellular Vesicles Play a Relevant Role in the Regenerative Activities of the Secretome of Apoptotic Peripheral Blood Mononuclear Cells”
Ischemic Heart Diseases
Johann Wojta, Thomas Marti
Gemma Vilahur - Catalan Institute of
Cardiovascular Sciences, Spain
“Cell- or Paracrine- Mediated Reparative Effects in the
Infarct Heart”
Young Investigator Nominee: Ines Goncalves - Medical University of Vienna, Austria
“Differences in Stem Cell Processing Lead to Distinct Secretomes Secretion - Implications for Differential Results of Previous Clinical Trials of Stem Cell Therapy for Myocardial Infarction”
Young Investigator Nominee: Tanja Wagner - Medical University of Vienna, Austria
“Extracellular Vesicles Play a Relevant Role in the Regenerative Activities of the Secretome of Apoptotic Peripheral Blood Mononuclear Cells”
16:25 - 17:30
Coffee & Posters
17:30 - 19:00
Chairs:
Chairs:
Humans Trials with ATMP-Secretome -
from Trachea, Skin and Valve Tissue
Marian Gyongyosi, Konrad Hoetzenecker
Jolanda Kluin - Academic Medical Center, Netherlands
“Valve Tissue - from Bench to Bedside” Christine Radtke - Medical University of Vienna, Austria
“Nerval Regeneration in Reconstructive Therapy”
Marian Gyongyosi - Medical University of Vienna, Austria
“Heart - Stem Cell Transplantation: Reality Check and Future”
Konrad Hoetzenecker - Medical University of Vienna, Austria
“Tracheal Transplantation - Current State - Future Aspects”
from Trachea, Skin and Valve Tissue
Marian Gyongyosi, Konrad Hoetzenecker
Jolanda Kluin - Academic Medical Center, Netherlands
“Valve Tissue - from Bench to Bedside” Christine Radtke - Medical University of Vienna, Austria
“Nerval Regeneration in Reconstructive Therapy”
Marian Gyongyosi - Medical University of Vienna, Austria
“Heart - Stem Cell Transplantation: Reality Check and Future”
Konrad Hoetzenecker - Medical University of Vienna, Austria
“Tracheal Transplantation - Current State - Future Aspects”
Programme
2nd Day:
Friday, 1st December 2017
08:30 - 09:40
Chairs: Keynote
Chairs: Keynote
Cellular Plasticity and Tissue Regeneration
Michael Comer, Ralph Schmid
Pier Lorenzo Puri -Sanford Burnham Prebys Medical
Discovery Institute, USA
“Molecular and Cellular Dynamics of Muscle Regeneration in Health and Disease” Thomas Marti - University Hospital Inselspital Bern, Switzerland
“Cellular Plasticity and Tissue Regeneration: What can We Learn from Tumor Biology” Sean Hall - University Hospital Inselspital Bern, Switzerland
“Optimization of a Human Lung Organoid Model for Lung Regeneration”
Michael Comer, Ralph Schmid
Pier Lorenzo Puri -Sanford Burnham Prebys Medical
Discovery Institute, USA
“Molecular and Cellular Dynamics of Muscle Regeneration in Health and Disease” Thomas Marti - University Hospital Inselspital Bern, Switzerland
“Cellular Plasticity and Tissue Regeneration: What can We Learn from Tumor Biology” Sean Hall - University Hospital Inselspital Bern, Switzerland
“Optimization of a Human Lung Organoid Model for Lung Regeneration”
09:40 - 10:10
Coffee
10:10 - 11:40
Chairs:
Chairs:
Inflammation & Immunology
Hannes Stockinger, Michael B. Fischer
Urs Eriksson - University of Zurich, GZO Regional Health Center, Switzerland
“Inflammation and Heart - Myocarditis and AMI” Christoph Binder - CEMM, Medical University of Vienna, Austria
“Humoral Immunity in the Inflamed Heart”
Young Investigator Nominee: Ljubica Mandic - Medical University of Vienna, Austria
“Enhanced Regenerative Effect of Cardiosphere-derived Cells by Pre-treatment with Paracrine Factor APOSEC in Porcine Closed-chest Reperfused Myocardial Infarction Proved by Quantitative Cardiac PET-MRI” Young Investigator Nominee: Severin Mühleder - Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Austrian Cluster for Tissue Regeneration, Austria
“Characterization of Engineered Vascular Networks Derived from Endothelial Cells and Adipose-derived Stem Cells in a Fibrin MatrixI”
Hannes Stockinger, Michael B. Fischer
Urs Eriksson - University of Zurich, GZO Regional Health Center, Switzerland
“Inflammation and Heart - Myocarditis and AMI” Christoph Binder - CEMM, Medical University of Vienna, Austria
“Humoral Immunity in the Inflamed Heart”
Young Investigator Nominee: Ljubica Mandic - Medical University of Vienna, Austria
“Enhanced Regenerative Effect of Cardiosphere-derived Cells by Pre-treatment with Paracrine Factor APOSEC in Porcine Closed-chest Reperfused Myocardial Infarction Proved by Quantitative Cardiac PET-MRI” Young Investigator Nominee: Severin Mühleder - Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Austrian Cluster for Tissue Regeneration, Austria
“Characterization of Engineered Vascular Networks Derived from Endothelial Cells and Adipose-derived Stem Cells in a Fibrin MatrixI”
11:40 - 12:50
Chairs:
Chairs:
Micro RNAs as Important Regulators
Johannes Grillari, Heinz Redl
Bernd Giebel - Universitätsklinikum Essen, Germany
“Therapeutic of MSC Evs”
Roland Kocijan - Krankenhaus der Barmherzigen Schwestern, Vienna, Austria
“Correlation Bone Structure and miRNA Plasma Levels”
Matthias Hackl - University of Natural Resources and Life Sciences (BOKU), Vienna, Austria
“miRNA Levels in a Model of Osteoporosis and Therapy”
Wolfgang Holnthoner - Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria
“Endothelial Extracellular Vesicles - Promises and Challenges”
Johannes Grillari, Heinz Redl
Bernd Giebel - Universitätsklinikum Essen, Germany
“Therapeutic of MSC Evs”
Roland Kocijan - Krankenhaus der Barmherzigen Schwestern, Vienna, Austria
“Correlation Bone Structure and miRNA Plasma Levels”
Matthias Hackl - University of Natural Resources and Life Sciences (BOKU), Vienna, Austria
“miRNA Levels in a Model of Osteoporosis and Therapy”
Wolfgang Holnthoner - Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria
“Endothelial Extracellular Vesicles - Promises and Challenges”
12:50 - 14:00
Lunch & Posters
14:00 - 15:40
Chairs:
Chairs:
Cell and Gene Therapy
Tobias Winkler, Dirk Strunk
Tobias Winkler - Charité, Berlin, Germany
“Placental Stromal Cells for Regeneration of Injured Gluteal Muscle after Hip Arthroplasty”
Christoph von Kalle - NCT Heidelberg, Germany
“Back to the Future - New Strategies in Gene Therapy”
Achim Schneeberger - Accanis, Vienna, Austria
“What if We Could Give the Body Instructions to Produce its Own Drugs?”
Dirk Strunk - Paracelsus Medical University Salzburg, Austria
“Why We Develop iPSC Therapy Strategies”
Tobias Winkler, Dirk Strunk
Tobias Winkler - Charité, Berlin, Germany
“Placental Stromal Cells for Regeneration of Injured Gluteal Muscle after Hip Arthroplasty”
Christoph von Kalle - NCT Heidelberg, Germany
“Back to the Future - New Strategies in Gene Therapy”
Achim Schneeberger - Accanis, Vienna, Austria
“What if We Could Give the Body Instructions to Produce its Own Drugs?”
Dirk Strunk - Paracelsus Medical University Salzburg, Austria
“Why We Develop iPSC Therapy Strategies”
15:40 - 16:10
Coffee
16:10 - 17:50
Chairs:
Chairs:
Mechano-Biological Aspects of Cell Behavior
Sean Hall, Heinz Redl
Giancarlo Forte - FNUSA-ICRC/St. Anne's University Hospital, Brno, Czech Republic
“Hippo Effector Protein YAP as the Master Regulator of Cell-Matrix Interaction in Health and Disease”
Johannes Holfeld - Medical University of Innsbruck, Austria
“Mechanical Stimulation by Shockwave Therapy Induces Myocardial Regeneration”
Philipp Heher - Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria
“The Importance of Mechanotransduction in Myogenesis”
Carolin Lindner - Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria
“Effects of Shockwave on Adipose Derived Stem Cells”
Johannes Holfeld - Medical University of Innsbruck, Austria
“Calcification of the heart valve by TLR3”
Sean Hall, Heinz Redl
Giancarlo Forte - FNUSA-ICRC/St. Anne's University Hospital, Brno, Czech Republic
“Hippo Effector Protein YAP as the Master Regulator of Cell-Matrix Interaction in Health and Disease”
Johannes Holfeld - Medical University of Innsbruck, Austria
“Mechanical Stimulation by Shockwave Therapy Induces Myocardial Regeneration”
Philipp Heher - Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria
“The Importance of Mechanotransduction in Myogenesis”
Carolin Lindner - Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria
“Effects of Shockwave on Adipose Derived Stem Cells”
Johannes Holfeld - Medical University of Innsbruck, Austria
“Calcification of the heart valve by TLR3”
17:50 - 18:00
Closing Remarks